Preheat oven to 350°F.
Beat cream cheese, pumpkin, sugar, vanilla, cinnamon and nutmeg in a large bowl with an electric mixer on medium speed until well blended. Add eggs; beat just until blended.
Pour mixture into crust.
Bake until the center is almost set, about 40 minutes. Take out of oven, let cool. Refrigerate at least 3 hours.