Each year, countless smokers resolve to finally quit their addiction once and for all. For Monica, April and Christine, this is easier said than done -- each has been smoking for over 20 years. In the most serious human lab experiment yet, these women agree to try three products that claim they will be able to extinguish their habit forever.

The E-Z Quit Smokeless Artificial Cigarette. Monica tries using these "fake" cigarettes, which claim to be a substitute for handling and drawing on a real cigarette. But she finds that the one characteristic lacking from E-Z Quit didn't help her addiction. "It doesn't really feel like I'm smoking a cigarette -- there's no nicotine in the product," Monica says. "I was suffering from withdrawal. I was cranky." Dr. Holly Phillips, a medical correspondent for WCBS, explains "Cigarette smoking is not just about that feeling in your hand -- the fake cigarette doesn't deal with the nicotine addiction."

Rachael shares the official statement from E-Z Quit. "They stand by their product and a 20-plus year record of success," she reads, "and they contend that no one-person test can be a true indicator of a product's effectiveness."

Craze-Rx Drops. Christine, who's been smoking since she was 13, adds Craze-Rx drops to her drinking water, an herbal remedy that is supposed to reduce her nicotine cravings. Despite her aversion to the flavor of the drops, Christine did notice that she was smoking less. "The cigarettes tasted so bad," she says after using the drops, "I was smoking a pack a day, and now I'm smoking two or three cigarettes a day." Dr. Phillips remarks that any reduction in smoking can be counted as victory.

Rachael reads the official statement from Crave-Rx: "For seasoned smokers," she reads, "they advise using two other products along with the drops. They say they are committed to helping people stop smoking."

New Life Laser Therapy. When April undergoes a laser treatment that claims to stimulate the release of endorphins to reduce her nicotine cravings, she finds the results surprising. "At the beginning, I didn't think it would work," she admits, "but I can honestly say it has worked for me. It's just reassured me that I could do anything that I put my mind to." Dr. Phillips offers her explanation of the product's success with April. "This treatment is supposed to act similar to acupuncture, which has been around for 5,000 years -- stimulating energy points, it's thought to have to do with endorphins in the body making you crave less." She also praises April by pointing out, "You seemed like you were not only ready to quit, but you were motivated, you were in the right place, and I think you have to take credit for this."

Rachael asks the doctor why it's so hard for medical science to come up with the one cure-all miracle product. "There's just no miracle cure for smoking," Dr. Phillips explains. "And smoking is very complicated -- there's the nicotine addiction, but then it also appeals to all of our senses. There's the visual sensation -- you have smoke around you. Some smokers say when they hear the cigarette lighting up they feel a certain way. There's the taste, and the tactile sensation of having the cigarette in your hand."

Dr. Phillips explains that if you're looking to quit smoking, there's no harm in trying different methods: "I always tell my patients, as long as the products aren't harmful, try whatever you need to do to quit."