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Preheat oven to 375˚F.
For the basic mac and cheese base, add the butter to a high-sided or deep skillet. Once the butter melts, add the flour and whisk one minute to make a roux. Whisk the milk into the roux. Simmer, stirring occasionally, until slightly thickened, 3 to 5 minutes. Stir in cheeses and stir until combined. Mix in white pepper, dry mustard, granulated onion and cayenne pepper.
For the garlic bread mixture/topping, melt butter in a small pot over medium heat, swirl butter with garlic a minute or 2, and toss with breadcrumbs to moisten. Combine with parsley, oregano, red chili flakes and Parm.
Combine the pasta with the mac and cheese base, then toss with half the breadcrumbs and add to a casserole dish. Top with remaining bread crumbs and more parm and bake until bubbly and brown on top, about 15 minutes.